流体が細胞や物質の表面に与える、流れに沿った方向の力のことを指します。マイクロ流体デバイスやバイオリアクターなどの流れを伴う培養系において、流速の勾配によって生じ、細胞にとっては重要な物理的刺激となります。灌流培養やorgan-on-a-chipなどの応用では、適切なせん断応力を与えることが、生体模倣性の高い実験系構築に不可欠です。

This refers to the force exerted by a fluid on the surface of cells or materials in the direction of flow. In flow-based culture systems, such as microfluidic devices and bioreactors, this force arises from gradients in flow velocity and serves as a critical physical stimulus for cells. In applications such as perfusion culture and organ-on-a-chip systems, the application of appropriate shear stress is essential for constructing experimental systems that closely mimic biological conditions.